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Vol.31No.5Oct.2019 河南医学高等专科学校学报JournalofHenanMedicalCollege
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雷公藤多苷治疗慢性肾小球肾炎的效果
赵光明
(台前县人民医院普内科ꎬ河南台前457600)
[摘要] 目的 探求采用雷公藤多苷片治疗慢性肾小球肾炎效果及对肾功能的影响ꎮ方法 选取慢性肾小球肾
炎患者96例ꎬ按单盲抽法将其分为对照组和观察组ꎬ各48例ꎮ对照组采用阿魏酸钠0.3gꎬ加入质量分数5%葡萄
糖注射液250mL中静脉滴注ꎬ1次/dꎬ观察组在此基础上口服雷公藤多苷片ꎬ20mg/次ꎬ3次/dꎬ2组均连续治疗3
个月后ꎬ比较2组临床疗效、肾功能以及不良反应ꎮ结果 治疗后ꎬ对照组总有效率75.00%ꎬ低于观察组的91.67%ꎻ对照组血尿素氮(BUN)(7.36±0.83)mmol/L、血肌酐(Scr)(86.32±7.24)μmmol/L及24h尿蛋白(24h
Upro)(1.03±0.12)gꎬ均高于观察组的(6.18±0.43)mmol/L、(75.03±6.27)μmmol/L及(0.69±0.20)gꎬ差异有
统计学意义(P<0.05)ꎻ2组不良反应发生率比较ꎬ差异无统计学意义(P>0.05)ꎮ结论 慢性肾小球肾炎在阿魏
酸钠治疗基础上加用雷公藤多苷片治疗ꎬ可改善患者肾功能ꎬ提高临床疗效ꎬ且不良反应少ꎬ安全性较高ꎮ
[关键词] 慢性肾小球肾炎ꎻ雷公藤多苷片ꎻ肾功能
[中图分类号] R692.3
+1 [文献标识码] A [文章编号] 1008-9276(2019)05-0593-03
ClinicalEfficacyofTripterygiumGlycosidesinthe
TreatmentofChronicGlomerulonephritis
ZHAOGuangming
(DepartmentofGeneralInternalMedicineꎬTaiqianCountyPeople’sHospitalꎬTaiqianHenan457600ꎬChina)
[Abstract] Objective Toinvestigatetheefficacyoftripterygiumglycosidesintreatmentofchronic
glomerulonephritisanditsinfluenceonrenalfunction.Methods 96patientswithchronicglomerulone ̄
phritiswereselectedꎬandtheyweredividedintocontrolgroupandobservationgroupbysingleblindse ̄
lectionmethodꎬwith48casesineachgroup.Controlgroupwasgivensodiumferulate0.3gꎬwithintrave ̄
efficacyꎬrenalfunctionꎬadversereactionswerecomparedbetweenthetwogroups.Results Aftertreat ̄
group[(7.36±0.83)mmol/Lꎬ(86.32±7.24)μmmol/Lꎬ(1.03±0.12)g]werehigherthanobser ̄
statisticallysignificant(P<0.05).Therewasnostatisticaldifferenceintheincidenceofadversereac ̄
efficacyꎬhaslessadversereactionsandhighersafety.
慢性肾小球肾炎是一种由多病因引起的以慢性
收稿日期:2018-07-23 修回日期:2019-02-11
作者简介:赵光明(1982-)ꎬ男ꎬ山东省金乡县人ꎬ学士ꎬ主治医师ꎬ从事内科临床工作ꎮ
nousinjectionof5%glucoseinjection250mLꎬgdꎬwhileobservationgroupwastreatedwithtripterygium
glycosides200mgorallyeverytimeꎬthreetimesadaybasedoncontrolgroup.After3 ̄monthꎬtheclinical
thebloodureanitrogen(BUN)ꎬserumcreatinine(Scr)ꎬ24hurineprotein(24hUpro)incontrol
mentꎬthetotaleffectiverateofcontrolgroup(75.00%)waslowerthanobservationgroup(91.67%)ꎬ
vationgroup[(6.18±0.43)mmol/Lꎬ(75.03±6.27)μmmol/Lꎬ(0.69±0.20)g]Thedifferencewas
tionsbetweenthetwogroups(P>0.05).Conclusion Tripterygiumglycosidescombinedwithsodium
ferulateintreatmentofchronicglomerulonephritiscaneffectivelyimproverenalfunctionꎬincreaseclinical
[Keywords] chronicglomerulonephritisꎻtripterygiumglycosidesꎻrenalfunction
肾小球病变为主的肾小球疾病ꎬ临床多表现为蛋白