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血清胱抑素C和尿微量白蛋白在慢性肾小球
肾炎早期肾功能损害评估中的意义
作者:周碧燕李友邕钟德斌覃政文延峰
来源:《中国医药导报》2011年第34期
[摘要]目的:探讨血清胱抑素C(CysC)和24h尿微量白蛋白(24hU-mAlb)在慢性肾
小球肾炎早期肾功能损害评估中的临床意义。方法:检测43例慢性肾小球肾炎早期肾功能损
害患者(观察组)血清CysC和24hU-mAlb水平,并与43例健康体检者(正常对照组)进
行对照分析。结果:慢性肾小球肾炎早期肾功能损害患者血清CysC、24hU-mAlb明显高于
正常对照组(P0.05)。结论:血清CysC和24hU-mAlb在慢性肾小球肾炎早期肾功能损害时
升高均较为灵敏,二者可作为慢性肾小球肾炎早期肾功能损害评估的敏感指标。
[关键词]慢性肾小球肾炎;血清胱抑素C;尿微量白蛋白
[中图分类号]R692.3[文献标识码]B[文章编号]1673-7210(2011)12(a)-095-02
ThesignificanceoftheserumCystatinCanduricmicroalbumininevaluatingtheearlyrenal
impairmentofthepatientswithchronicglomerulonephritis
ZHOUBiyan,LIYouyong,ZHONGDebin,QINZheng,WENYanfeng
DepartmentofClinicalLaboratory,theFirstPeople′sHospitalofNanningCity,GuangxiZhuang
AutonomousRegion,Nanning530022,China
[Abstract]Objective:TostudytheclinicalsignificanceoftheserumCystatinC(CysC)anduric
microalbuminwithin24hours(24hU-mAlb)intheearlyrenalimpairmentofthepatientswith
s:TheserumCysCand24hU-mAlbof43patientswithchronic
glomerulonephritis(observationgroup)weredetectedandcomparedwiththoseof43healthysubjects
(controlgroup).Results:TheserumCysCand24hU-mAlbintheobservationgroupwerehigher
remarkablythanthoseinthecontrolgroup(P0.05).Conclusion:TheserumCysCand24hU-mAlb
areallsensitiveinevaluatingtherenalimpairmentofthepatientswithchronicglomerulonephritis,
andcanbecometwosensitiveindicatorsforevaluatingtheearlyrenalimpairmentofthepatientswith
chronicglomerulonephritis.
[Keywords]Chronicglomerulonephritis;SerumcystatinC;Uricmicroalbumin
慢性肾小球肾炎(chronicglomerulonephritis)简称为慢性肾炎,系指由各种病原微生物感
染通过免疫及非免疫机制等引起的双侧肾小球弥漫性或局灶性炎症性改变,以蛋白尿、血尿、